Document Type

Article

Publication Date

3-20-2013

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.

DOI

10.1128/JVI.00375-13

Original Citation

Liang X, Crepeau RL, Zhang W, Speck SH, Usherwood EJ. CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth. J Virol. 2013 May;87(10):6051-4. doi: 10.1128/JVI.00375-13. Epub 2013 Mar 20. PMID: 23514885; PMCID: PMC3648166.

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