Document Type

Article

Publication Date

9-2009

Publication Title

BioMed Central Gastroenterology

Department

Geisel School of Medicine

Abstract

Differentiated pancreatic acinar cells expressing endogenous levels of mutant K-Ras do not spontaneously develop pancreatic ductal adenocarcinoma (PDAC). However, we hypothesized that acinar cells would develop PDAC in the presence of Ras activity levels mimicking those of human tumor cells.We measured Ras activity in PDAC cells from mice and humans using a Raf pull-down assay. We compared the effects of acinar cell expression of mutant K-Ras at endogenous and elevated levels on Ras activity and on the development of PDAC.

DOI

10.1053/j.gastro.2009.05.052

Original Citation

Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, Daniluk J, Bi Y, Grote T, Longnecker DS, Logsdon CD. Ras activity levels control the development of pancreatic diseases. Gastroenterology. 2009 Sep;137(3):1072-82, 1082.e1-6. doi: 10.1053/j.gastro.2009.05.052. Epub 2009 Jun 6. Erratum in: Gastroenterology. 2011 May;140(5):1696. PMID: 19501586; PMCID: PMC2789008.

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