The immune modulation on innate immunity, from pathogen recognition to fungal clearance., Ko-Wei Liu
Dartmouth College Ph.D Dissertations

RESPONSE AND MOLECULAR CONTROL OF CD8 T CELLS DURING INFECTION AND CANCER, Nicholas K. Preiss Dr.
Dartmouth College Ph.D Dissertations

Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses, Lynn Enquist, David A. Leib
Dartmouth Scholarship

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation, Vicente Mas, Laura Rodriguez, Eduardo Olmedillas, Olga Cano, Concepcion Palomo, Maria C. Terron, Daniel Luque, Jose A. Melero, Jason S. McLellan
Dartmouth Scholarship

Building from the HIV Response toward Universal Health Coverage, Jonathon Jay, Kent Buse, Marielle Hart, Robert Marten, Scott Kellerman, Morolake Odetoyinbo, Jonathan D. Quick, Timothy Evans, Peter Piot, Mark Dybul, Agnes Binagwaho
Dartmouth Scholarship

The Toxoplasma Gondii Rhoptry Kinome is Essential for Chronic Infection, Barbara A. Fox, Leah M. Rommereim, Rebekah B. Guevara, Alejandra Falla, Miryam Andrea Hortua Triana, Yanbo Sun, David J. Bzik
Dartmouth Scholarship

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles, Katja Koeppen, Thomas H. Hampton, Michael Jarek, Maren Scharfe, Scott A. Gerber, Daniel W. Mielcarz, Elora G. Demers, Emily L. Dolben, John H. Hammond, Deborah A. Hogan, Bruce A. Stanton
Dartmouth Scholarship

MicroRNA miR-155 Is Necessary for Efficient Gammaherpesvirus Reactivation from Latency, but Not for Establishment of Latency, Rebecca L. Crepeau, Peisheng Zhang, Edward J. Usherwood
Dartmouth Scholarship

A Retroviral CRISPR-Cas9 System for Cellular Autism-Associated Phenotype Discovery in Developing Neurons, Michael R. Williams, Catherine J. Fricano-Kugler, Stephanie A. Getz, Patrick D. Skelton, Jeonghoon Lee, Christian P. Rizzuto, Joseph S. Geller, Meijie Li, Bryan W. Luikart
Dartmouth Scholarship

Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons, Sarah Katzenell, David A. Leib
Dartmouth Scholarship

Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1, Zachary M. Parker, Aisling A. Murphy, David. A. Leib
Dartmouth Scholarship

Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus, Kathy A. Green, Li Wang, Randolph J. Noelle, William R. Green
Dartmouth Scholarship

MCL1 Enhances the Survival of CD8+ Memory T Cells after Viral Infection, Jingang Gui, Zhuting Hu, Ching-Yi Tsai, Tian Ma, Yan Song, Amanda Morales, Li-Hao Huang, Ethan Dmitrovsky, Ruth Craig, Edward Usherwood
Dartmouth Scholarship

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4, Neeltje van Doremalen, Kerri L. Miazgowicz, Shauna Milne-Price, Trenton Bushmaker, Shelly Robertson, Dana Scott, Joerg Kinne, Jason S. McLellan
Dartmouth Scholarship

Intrinsic Innate Immunity Fails To Control Herpes Simplex Virus and Vesicular Stomatitis Virus Replication in Sensory Neurons and Fibroblasts, Pamela C. Rosato, David A. Leib
Dartmouth Scholarship

Use of IRF-3 and/or IRF-7 Knockout Mice To Study Viral Pathogenesis: Lessons from a Murine Retrovirus-Induced AIDS Model, Megan A. O'Connor, William R. Green
Dartmouth Scholarship

Divergent Antibody Subclass and Specificity Profiles but Not Protective HLA-B Alleles Are Associated with Variable Antibody Effector Function among HIV-1 Controllers, Jennifer I. Lai, Anna F. Licht, Anne-Sophie Dugast, Todd Suscovich, Ickwon Choi, Chris Bailey-Kellogg, Galit Alter, Margaret E. Ackerman
Dartmouth Scholarship

The Role of Indoleamine 2,3-Dioxygenase in LP-BPM5 Murine Retroviral Disease Progression, Megan A. O'Connor, William R. Green
Dartmouth Scholarship

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for FcγR2a and FcγR2b, Margaret E. Ackerman, Anne-Sophie Dugast, Elizabeth G. McAndrew, Stephen Tsoukas
Dartmouth Scholarship

CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth, Xiaozhan Liang, Rebecca L. Crepeau, Weijun Zhang, Samuel H. Speck, Edward J. Usherwood
Dartmouth Scholarship

Inhibition of the Host Translation Shutoff Response by Herpes Simplex Virus 1 Triggers Nuclear Envelope-Derived Autophagy, Kerstin Radtke, Luc English, Christiane Rondeau, David Leib
Dartmouth Scholarship

Myeloid-Derived Suppressor Cells in Murine Retrovirus-Induced AIDS Inhibit T- and B-Cell Responses In Vitro That Are Used To Define the Immunodeficiency, Kathy A. Green, W. James Cook, William R. Green
Dartmouth Scholarship

MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation, Ching-Yi Tsai, S. Rameeza Allie, Weijun Zhang, Edward J. Usherwood
Dartmouth Scholarship

Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff, Tracy J. Pasieka, Vineet D. Menachery, Pamela C. Rosato, David A. Leib
Dartmouth Scholarship

Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal Infection, Tracy J. Pasieka, Cristian Cilloniz, Victoria S. Carter, Pamela Rosato, Michael G. Katze, David A. Leib
Dartmouth Scholarship

Impaired Memory Cd8 T-Cell Responses Against an Immunodominant Retroviral Cryptic Epitope, Melanie R. Rutkowski, Cynthia A. Stevens, William R. Green
Dartmouth Scholarship

Superparamagnetic Nanoparticle Capture of Prions for Amplification, Michael B. Miller, Surachai Supattapone
Dartmouth Scholarship

Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection, Vineet D. Menachery, Tracy J. Pasieka, David A. Leib
Dartmouth Scholarship

Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection, Michael Molloy, Weijun Zhang, Edward Usherwood
Dartmouth Scholarship

Primary Human Mammary Epithelial Cells Endocytose HIV-1 and Facilitate Viral Infection of CD4+ T Lymphocytes, Stephanie M. Dorosko, Ruth I. Connor
Dartmouth Scholarship

Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12, Teddy F. Mselle, Aexandra L. Howell, Mimi Ghosh, Charles R. Wira, Charles L. Sentman
Dartmouth Scholarship

Gammaherpesvirus Persistence Alters Key CD8 T-Cell Memory Characteristics and Enhances Antiviral Protection, Joshua J. Obar, Shinichiro Fuse, Erica K. Leung, Sarah C. Bellfy, Edward J. Usherwood
Dartmouth Scholarship

CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68, Shinichiro Fuse, Joshua J. Obar, Sarah Bellfy, Erica K. Leung, Weijun Zhang, Edward J. Usherwood
Dartmouth Scholarship

The Role of CD4 T Cells in the Pathogenesis of Murine AIDS, Wen Li, William R. Green
Dartmouth Scholarship

T-Cell Responses to the M3 Immune Evasion Protein of Murid Gammaherpesvirus 68 Are Partially Protective and Induced with Lytic Antigen Kinetics, Joshua J. Obar, Douglas C. Donovan, Sarah G. Crist, Ondine Silvia, James P. Stewart, Edward J. Usherwood
Dartmouth Scholarship

CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Cory L. Ahonen, W. James Cook, William R. Green
Dartmouth Scholarship

The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules, Kathy A. Green, W. James Cook, Arlene H. Sharpe, William R. Green
Dartmouth Scholarship

Identification of a Novel Antiapoptotic Functional Domain in Simian Virus 40 Large T Antigen., Suzanne D. Conzen, Christine A. Snay, Charles N. Cole
Dartmouth Scholarship

Activation of the Human Thymidine Kinase (TK) Promoter by Simian Virus 40 Large T Antigen Requires Both the T Antigen pRb Family-binding Domain and TK Promoter Sequences Resembling E2F-binding Sites., Michelle M. Anderson, Jun Chen, Charles N. Cole, Susan E. Conrad
Dartmouth Scholarship

Antibody to the Ligand for CD40 (gp39) Inhibits Murine AIDS-associated Splenomegaly, Hypergammaglobulinemia, and Immunodeficiency in Disease-Susceptible C57BL/6 Mice., Kathy A. Green, Karen M. Crassi, Jon D. Laman, Arjan Schoneveld, Rendall R. Strawbridge, Teresa M. Foy, Randolph J. Noelle, William R. Green
Dartmouth Scholarship

Transactivation of the Moloney Murine Leukemia Virus and T-cell Receptor Beta-Chain Enhancers by cbf and ets Requires Intact Binding Sites for Both Proteins., Wanwen Sun, Barbara J. Graves, Nancy A. Speck
Dartmouth Scholarship

A TEF-1-independent Mechanism for Activation of the Simian Virus 40 (SV40) Late Promoter by Mutant SV40 Large T Antigens., Paul Casaz, Phillip W. Rice, Charles N. Cole, Ulla Hansen
Dartmouth Scholarship

Transcriptional Activity of Core Binding Factor-Alpha (AML1) and Beta Subunits on Murine Leukemia Virus Enhancer Cores., Ari L. Zaiman, Amy F. Lewis, Barbara E. Crute, N. A. Speck, Jack Lenz
Dartmouth Scholarship

A Novel Translational Regulation Function for the Simian Virus 40 Large-T Antigen Gene., Prithi Rajan, Sathyamagalam Swaminathan, Jiyue Zhu, Charles N. Cole
Dartmouth Scholarship

Adoptive Transfer of Polyclonal and Cloned Cytolytic T Lymphocytes (CTL) Specific for Mouse AIDS-associated Tumors is Effective in Preserving CTL Responses: A Measure of Protection Against LP-BM5 Retrovirus-induced Immunodeficiency., William R. Green, Kathy A. Green, Karen M. Crassi
Dartmouth Scholarship

The Amino-terminal Functions of the Simian Virus 40 Large T Antigen Are Required to Overcome Wild-type p53-Mediated Growth Arrest of Cells., Robin S. Quartin, Charles N. Cole, James M. Pipas, Arnold J. Levine
Dartmouth Scholarship

Efficient Transcriptional Activation of Many Simple Modular Promoters by Simian Virus 40 Large T Antigen., Philip W. Rice, Charles N. Cole
Dartmouth Scholarship

Molecular Cloning of Infectious Ecotropic Murine Leukemia Virus AK7 from an emv-14-positive AKXL-5 Mouse and the Resistance of AK7 to Recognition by Cytotoxic T Lymphocytes., Hillary D. White, William R. Green, Nuria R. Giné
Dartmouth Scholarship

Characterization of a Protein that Binds Multiple Sequences in Mammalian Type C Retrovirus Enhancers., Wanwen Sun, Mary M. O'Connell, Nancy A. Speck
Dartmouth Scholarship

Two Factors that Bind to Highly Conserved Sequences in Mammalian Type C Retroviral Enhancers., Nancy R. Manley, Mary M. O'Connell, Wanwen Sun, Nancy A. Speck, Nancy Hopkins
Dartmouth Scholarship

Transformation of a Continuous Rat Embryo Fibroblast Cell Line Requires Three Separate Domains of Simian Virus 40 Large T Antigen., Jiyue Zhu, Philip W. Rice, Lisa Gorsch, Marina Abate, Charles N. Cole
Dartmouth Scholarship

Cytolytic T Lymphocytes Specific for Tumors and Infected Cells from Mice with a Retrovirus-induced Immunodeficiency Syndrome., Jennifer G. Erbe, Kathy A. Green, Karen M. Crassi, Herbert C. Morse, W R. Green
Dartmouth Scholarship

The Ability of Simian Virus 40 Large T Antigen to Immortalize Primary Mouse Embryo Fibroblasts Cosegregates with its Ability to Bind to P53., Jiyue Y. Zhu, Marina Abate, Philip W. Rice, Charles N. Cole
Dartmouth Scholarship

Mapping the Transcriptional Transactivation Function of Simian Virus 40 Large T Antigen., Jiyue Y. Zhu, Philip W. Rice, Michele Chamberlain, Charles N. Cole
Dartmouth Scholarship

The Growth of Simian Virus 40 (SV40) Host Range/Adenovirus Helper Function Mutants in an African Green Monkey Cell Line that Constitutively Expresses the SV40 Agnoprotein., Terryl P. Stacy, Michele Chamberlain, Susan Carswell, Charles N. Cole
Dartmouth Scholarship

Mechanism of Escape of Endogenous Murine Leukemia Virus EMV-14 from Recognition by Anti-AKR/Gross Virus Cytolytic T Lymphocytes., Hillary D. White, Michael D. Robbins, William R. Green
Dartmouth Scholarship

Simian Virus 40 Host Range/Helper Function Mutations Cause Multiple Defects in Viral Late Gene Expression., Terryl Stacy, Michele Chamberlain, Charles N. Cole
Dartmouth Scholarship

Linker Insertion Mutants of Simian Virus 40 Large T Antigen that Show Trans-Dominant Interference with Wild-Type Large T Antigen Map to Multiple Sites within the T-antigen Gene., Jiyue Y. Zhu, Charles N. Cole
Dartmouth Scholarship

Absence of a Structural Basis for Intracellular Recognition and Differential Localization of Nuclear and Plasma Membrane-Associated Forms of Simian Virus 40 Large Tumor Antigen., Donald L. Jarvis, Charles N. Cole, Janet S. Butel
Dartmouth Scholarship

Two Separable Functional Domains of Simian Virus 40 Large T Antigen: Carboxyl-terminal Region of Simian Virus 40 Large T Antigen is Required for Efficient Capsid Protein Synthesis., Joanne Tornow, Maryellen Polvino-Bodnar, George Santangelo, Charles N. Cole
Dartmouth Scholarship