Although angiogenesis (new blood vessel formation) is an absolute requirement for tumor growth, therapies designed to treat cancer by targeting specific angiogenic factors have had limited success. One theory is that there are many different angiogenic factors that can compensate for the loss of a single factor. Therefore, a more effective strategy may be to move upstream, identify a factor that regulates the expression of many different downstream angiogenic mediators, and then measure the effect of blocking this single common factor on angiogenesis-mediated tumor growth.
Norwitz, Nicholas G.
"Going for the Trunk,"
Dartmouth Undergraduate Journal of Science: Vol. 19
, Article 7.
Available at: https://digitalcommons.dartmouth.edu/dujs/vol19/iss3/7