ENGS 86 Independent Projects (AB Students)

Author ISNI

N/A

Degree Program

B.E.

Year of Graduation

2020

Faculty Advisor

Rahul Sarpeshkar

Document Type

Thesis (Senior Honors)

Publication Date

Spring 6-10-2020

Abstract

The field of bioengineering has much promise for renewable chemical production, bioremediation, and of course medical applications. Developing new useful microorganisms is extremely time and capital intensive, typically taking 50 million USD and eight years. This is due in large part to the low throughput techniques that are characteristic of the field of metabolic engineering. Here we describe the modification of an existing synthetic biosensor to measure the pharmaceutical dopamine, and the use of a circuit simulator Cadence to predict improvements to the biosensor. This biosensor paired with directed evolution techniques could reach throughputs of 5 million cells per day and be a rapid avenue for generating useful microbes at low cost.

Available for download on Thursday, June 10, 2021

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