ENGS 86 Independent Projects (AB Students)

Degree Program


Year of Graduation


Faculty Advisor

John XJ Zhang

Document Type


Publication Date

Winter 3-11-2019


Nanosensors utilizing the phenomenon of localized surface plasmon resonance (LSPR) have been gaining in popularity due to improved sensitivity and wider dynamic range of optical sensors. Liquid biopsy is a minimally invasive method of analyzing disease dynamics and many technologies have been developed for research laboratory settings. However, there remains a need to simplify the workflow and expand these technologies into point-of-care clinical settings. Functionalized gold nanoparticles dispersed on-chip represent a promising solution to this problem and could also be easily multiplexed to detect many different biomarkers on a single-chip. We are focused on the KRAS G12V point mutation of pancreatic cancer as the biomarker for our versatile multiplexed functionalized nanorods on-chip platform. We demonstrate a replicable fabrication method for multiplexed nanorods on-chip with the capability of selectively sensing KRAS mutations in ctDNA across a range of concentrations, a promising step forward for point-of-care clinical applications.

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