Year of Graduation
P. Jack Hoopes
Thesis (Senior Honors)
In this study MC38 (murine colon adenocarcinoma) and B16F10 (murine melanoma) cellular responses to equivalent gamma and x-ray radiation doses were examined. The results of colony forming assay survival fractions indicate MC38 cells are more sensitive to radiation than B16F10 cells. Additionally, MC38 cells are more susceptible to gamma radiation than x-ray radiation at any given dose, whereas the opposite is true for B16F10 cells indicating potentially important comparative differences (gamma vs x-ray) in cell survival. Western blot protein analysis and NanoString mRNA analysis for gamma radiation of B16F10 cells demonstrated small changes in the expression of cell death regulators.
Dartmouth Digital Commons Citation
Kossmann, Shannon, "Biological and Genetic Comparison of X-Ray and Gamma Ray Radiation Effects" (2020). ENGS 88 Honors Thesis (AB Students). 18.