ENGS 89/90 Reports

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Ian Baker


Solomon Diamond

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Current fixation between the prosthetic and bone is provided by two methods, PMMA bone cements and press-fit adherence, which exhibit problems of aseptic loosening responsible for the majority of late-term revision surgeries. Current drawbacks of fixation methods may be addressed by the use of a novel adhesive developed by RevBio, Tetranite. In addition to its unprecedented biocompatibility and bioresorbability, this mineral organic adhesive material can provide adhesion strength that is approximately 7.5x that of PMMA bone cements and sets into porous structures, providing a scaffold for bone tissue ingrowth. Tetranite’s favorable characteristics can address disadvantages of current fixation methods but due to a lack of preliminary data of Tetranite’s fixation strength in total joint implant surgeries, we were not yet able to validate the use of Tetranite as an appropriate fixation method. To analyze the fixation strength of Tetranite at the joint implant interface, we modeled the interaction of Tetranite between a metallic implant and the bone by using machinable analogs, a Ti-6Al-4V cylindrical rod and bone foam (of different densities) respectively. The mechanical properties of Tetranite were assessed by performing pull-out testing with an Instron machine to obtain max pull-out load, shear strength, and energy to failure as an approximation of fixation strength in comparison to PMMA bone cement. Our data and statistical analysis suggests that as a form of fixation, Tetranite is comparable to PMMA and can also address disadvantages of current fixation methods by offering better bioresorbability and biocompatibility.

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