Journal of Bacteriology
Geisel School of Medicine
The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.
Cheung AL, Nishina K, Manna AC. SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression. J Bacteriol. 2008 Mar;190(6):2239-43. doi: 10.1128/JB.01826-07. Epub 2008 Jan 4. PMID: 18178734; PMCID: PMC2258893.
Dartmouth Digital Commons Citation
Cheung, Ambrose L.; Nishina, Koren; and Manna, Adhar C., "SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression" (2007). Dartmouth Scholarship. 1084.