Journal of NeuroEngineering and Rehabilitation
The laryngeal chemoreflex exists in infants as a primary sensory mechanism for defending the airway from the aspiration of liquids. Previous studies have hypothesized that prolonged apnea associated with this reflex may be life threatening and might be a cause of sudden infant death syndrome. In this study we quantified the output of the respiratory neural network, the diaphragm EMG signal, during the laryngeal chemoreflex and eupnea in early postnatal (3–10 days) piglets. We tested the hypothesis that diaphragm EMG activity corresponding to reflex-related events involved in clearance (restorative) mechanisms such as cough and swallow exhibit lower complexity, suggesting that a synchronized homogeneous group of neurons in the central respiratory network are active during these events. Nonlinear dynamic analysis was performed using the approximate entropy to asses the complexity of respiratory patterns.
Dragomir, Andrei; Akay, Yasemin; Curran, Aidan K.; and Akay, Metin, "Investigating the Complexity of Respiratory Patterns During the Laryngeal Chemoreflex" (2008). Open Dartmouth: Faculty Open Access Articles. 1175.