Sonic hedgehog (Shh) and components of its signalling pathway have been identified in human prostate carcinoma and increased levels of their expression appear to correlate with disease progression and metastasis. The mechanism through which Shh signalling could promote metastasis in bone, the most common site for prostate carcinoma metastasis, has not yet been investigated. The present study determined the effect of Shh signalling between prostate cancer cells and pre-osteoblasts on osteoblast differentiation, a requisite process for new bone formation that characterizes prostate carcinoma metastasis.
Zunich, Samantha M; Douglas, Taneka; Valdovinos, Maria; and Chang, Tiffany, "Paracrine Sonic Hedgehog Signalling by Prostate Cancer Cells Induces Osteoblast Differentiation" (2009). Open Dartmouth: Faculty Open Access Articles. 1185.