Document Type
Article
Publication Date
2011
Publication Title
ASN Neuro
Department
Geisel School of Medicine
Additional Department
Thayer School of Engineering
Abstract
GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent models for preclinical studies. In this review, we highlight the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease. We end with a comprehensive review of the CNS-1 rodent model.
DOI
10.1042/AN20110014
Dartmouth Digital Commons Citation
Jacobs, Valerie L.; Valdes, Pablo A.; Hickey, William F.; and De Leo, Joyce A., "Current Review of In Nivo GBM Rodent Models: Emphasis on the CNS-1 Tumour Model" (2011). Dartmouth Scholarship. 1216.
https://digitalcommons.dartmouth.edu/facoa/1216