Journal of Virology
Geisel School of Medicine
Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.
Pasieka TJ, Menachery VD, Rosato PC, Leib DA. Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff. J Virol. 2012 Jul;86(14):7692-5. doi: 10.1128/JVI.00761-12. Epub 2012 May 2. PMID: 22553331; PMCID: PMC3416281.
Dartmouth Digital Commons Citation
Pasieka, Tracy J.; Menachery, Vineet D.; Rosato, Pamela C.; and Leib, David A., "Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff" (2012). Dartmouth Scholarship. 1231.