Journal of Virology
MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.
Tsai, Ching-Yi; Allie, S. Rameeza; Zhang, Weijun; and Usherwood, Edward J., "MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation" (2012). Open Dartmouth: Faculty Open Access Articles. 1254.