Journal of Virology
Geisel School of Medicine
There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.
Liang X, Crepeau RL, Zhang W, Speck SH, Usherwood EJ. CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth. J Virol. 2013 May;87(10):6051-4. doi: 10.1128/JVI.00375-13. Epub 2013 Mar 20. PMID: 23514885; PMCID: PMC3648166.
Dartmouth Digital Commons Citation
Liang, Xiaozhan; Crepeau, Rebecca L.; Zhang, Weijun; Speck, Samuel H.; and Usherwood, Edward J., "CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth" (2013). Dartmouth Scholarship. 1276.