Document Type

Article

Publication Date

1-16-2009

Publication Title

Cellular Physiology and Biochemistry

Abstract

P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to test the hypothesis that Corr4a and VRT325, investigational compounds that increase ΔF508-CFTR mediated Cl secretion in human CF airway cells, reduce the pro-inflammatory response to P. aeruginosa.

DOI

10.1159/000204108

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