Document Type

Article

Publication Date

12-11-2013

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.

DOI

10.1128/JVI.02960-13

Original Citation

O'Connor MA, Green WR. Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol. 2014 Feb;88(4):2349-53. doi: 10.1128/JVI.02960-13. Epub 2013 Dec 11. PMID: 24335302; PMCID: PMC3911529.

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