Journal of Virology
Geisel School of Medicine
Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.
O'Connor MA, Green WR. Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol. 2014 Feb;88(4):2349-53. doi: 10.1128/JVI.02960-13. Epub 2013 Dec 11. PMID: 24335302; PMCID: PMC3911529.
Dartmouth Digital Commons Citation
O'Connor, Megan A. and Green, William R., "Use of IRF-3 and/or IRF-7 Knockout Mice To Study Viral Pathogenesis: Lessons from a Murine Retrovirus-Induced AIDS Model" (2013). Dartmouth Scholarship. 1292.