Influenza is a common respiratory virus and Staphylococcus aureus frequently causes secondary pneumonia during influenza infection, leading to increased morbidity and mortality. Influenza has been found to attenuate subsequent Type 17 immunity, enhancing susceptibility to secondary bacterial infections. IL-27 is known to inhibit Type 17 immunity, suggesting a potential critical role for IL-27 in viral and bacterial co-infection.
Robinson, Keven M.; Lee, Benjamin; Scheller, Erich V; Mandalapu, Sivanarayana; and Enelow, Richard I., "The Role of IL-27 in Susceptibility to Post-Influenza Staphylococcus Aureus Pneumonia" (2015). Open Dartmouth: Faculty Open Access Articles. 1317.