Chromosomal Copy Number Alterations for Associations of Ductal Carcinoma in Situ with Invasive Breast Cancer

Anosheh Afghahi
Erna Forgó
Aya A. Mitani
Manisha Desai

Anosheh Afghahi;Erna Forgó;Aya Mitani;Manisha Desai;Sushama Varma;Tina Seto;Joseph Rigdon;Kristin Jensen;Megan Troxell;Scarlett Lin Gomez;Amar Das;Andrew Beck;Allison Kurian;Robert West


IntroductionScreening mammography has contributed to a significant increase in the diagnosis of ductal carcinoma in situ (DCIS), raising concerns about overdiagnosis and overtreatment. Building on prior observations from lineage evolution analysis, we examined whether measuring genomic features of DCIS would predict association with invasive breast carcinoma (IBC). The long-term goal is to enhance standard clinicopathologic measures of low- versus high-risk DCIS and to enable risk-appropriate tr