MicroRNAs have been identified as potential cancer biomarkers due to their presence and stability in many body fluids including urine and plasma, but the relationship of the pattern of expression of these messengers across various biological media has not been addressed and could provide important information in order to translate these biomarkers for epidemiologic or clinical use. We analyzed microRNA of matched FFPE-tumor tissue, plasma, urine exosomes (n = 16) and WBCs (n = 11) from patients with bladder cancer, using Nanostring miRNA assays and droplet digital PCR for validation. Pearson correlations were used to compare expression between media.
Dartmouth Digital Commons Citation
Armstrong, David A.; Green, Benjamin B.; Seigne, John D.; Schned, Alan R.; and Marsit, Carmen, "MicroRNA Molecular Profiling from Matched Tumor and Bio-Fluids in Bladder Cancer" (2015). Dartmouth Scholarship. 1338.