Journal of Virology
Geisel School of Medicine
Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.
Enquist LW, Leib DA. Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses. J Virol. 2016 Dec 16;91(1):e01200-16. doi: 10.1128/JVI.01200-16. PMID: 27795407; PMCID: PMC5165195.
Dartmouth Digital Commons Citation
Enquist, Lynn and Leib, David A., "Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses" (2017). Dartmouth Scholarship. 1367.