Proceedings of the National Academy of Sciences of the United States of America
Thayer School of Engineering
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
Brooksby B, Pogue BW, Jiang S, Dehghani H, Srinivasan S, Kogel C, Tosteson TD, Weaver J, Poplack SP, Paulsen KD. Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8828-33. doi: 10.1073/pnas.0509636103. Epub 2006 May 26. PMID: 16731633; PMCID: PMC1482663.
Dartmouth Digital Commons Citation
Brooksby, Ben; Pogue, Brian W.; Jiang, Shudong; Dehghani, Hamid; Srinivasan, Subhadra; Kogel, Christine; Tosteson, Tor D.; Weaver, John; Poplack, Steven P.; and Paulsen, Keith D., "Imaging Breast Adipose and Fibroglandular Tissue Molecular Signatures by Using Hybrid MRI-Guided Near-Infrared Spectral Tomography" (2006). Dartmouth Scholarship. 1399.