PLoS Computational Biology
Geisel School of Medicine
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
Mehra A, Hong CI, Shi M, Loros JJ, Dunlap JC, Ruoff P. Circadian rhythmicity by autocatalysis. PLoS Comput Biol. 2006 Jul 28;2(7):e96. doi: 10.1371/journal.pcbi.0020096. Epub 2006 Jun 8. PMID: 16863394; PMCID: PMC1523307.
Dartmouth Digital Commons Citation
Mehra, Arun; Hong, Christian I.; Shi, Mi; Loros, Jennifer J.; Dunlap, Jay C.; and Ruoff, Peter, "Circadian Rhythmicity by Autocatalysis" (2006). Dartmouth Scholarship. 1400.