Document Type
Article
Publication Date
7-28-2006
Publication Title
PLoS Computational Biology
Department
Geisel School of Medicine
Abstract
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
DOI
10.1371/journal.pcbi.0020096
Original Citation
Mehra A, Hong CI, Shi M, Loros JJ, Dunlap JC, Ruoff P. Circadian rhythmicity by autocatalysis. PLoS Comput Biol. 2006 Jul 28;2(7):e96. doi: 10.1371/journal.pcbi.0020096. Epub 2006 Jun 8. PMID: 16863394; PMCID: PMC1523307.
Dartmouth Digital Commons Citation
Mehra, Arun; Hong, Christian I.; Shi, Mi; Loros, Jennifer J.; Dunlap, Jay C.; and Ruoff, Peter, "Circadian Rhythmicity by Autocatalysis" (2006). Dartmouth Scholarship. 1400.
https://digitalcommons.dartmouth.edu/facoa/1400