Proceedings of the National Academy of Sciences of the United States of America
The coordinated regulation of chemokine responsiveness plays a critical role in the development of humoral immunity. After antigen challenge and B cell activation, the emerging plasma cells (PCs) undergo CXCL12-induced chemotaxis to the bone marrow, where they produce Ab and persist. Here we show that PCs, but not B cells or T cells from lupus-prone NZM mice, are deficient in CXCL12-induced migration. PC unresponsiveness to CXCL12 results in a marked accumulation of PCs in the spleen of mice, and a concordant decrease in bone marrow PCs. Unlike normal mice, in NZM mice, a majority of the splenic PCs are long-lived. This deficiency is a consequence of the genetic interactions of multiple systemic lupus erythematosus susceptibility loci.
Erickson, Loren D.; Lin, Ling-Li; Duan, Biyan; Morel, Laurence; and Noelle, Randolph J., "A GeneticLesion that Arrests Plasma Cell Homing to the Bone Marrow" (2003). Open Dartmouth: Faculty Open Access Articles. 1473.