Document Type

Article

Publication Date

10-27-2008

Publication Title

Optics Express

Department

Thayer School of Engineering

Abstract

Combined Magnetic Resonance (MR) and Near Infrared Spectroscopy (NIRS) has been proposed as a unique method to quantify hemodynamics, water content, and cellular size and packing density of breast tumors, as these tissue constituents can be quantified with increased resolution and overlaid on the structural features identified by the MR. However, the choices in how to reconstruct and visualize this information can have a dramatic impact on the feasibility of implementing this modality in the clinic. This is especially true in 3 dimensions, as there is often limited optical sampling of the breast tissue, and methods need to accurately reflect the tissue composition. In this paper, the implementation and display of fully 3D MR image-guided NIRS is outlined and demonstrated using in vivo data from three healthy women and a volunteer undergoing neoadjuvant chemotherapy. Additionally, a display feature presented here scales the transparency of the optical images to the sensitivity of the measurements, providing a logical way to incorporate partial volume sets of optical images onto the MR volume. These concepts are demonstrated with 3D data sets using Volview software online.

DOI

10.1364/oe.16.17903

Original Citation

Carpenter CM, Srinivasan S, Pogue BW, Paulsen KD. Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors. Opt Express. 2008 Oct 27;16(22):17903-14. doi: 10.1364/oe.16.17903. PMID: 18958072; PMCID: PMC2613302.

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