Genomic Reconstruction of Shewanella Oneidensis MR-1 Metabolism Reveals a Previously Uncharacterized Machinery for Lactate Utilization
Grigory E. Pinchuk;Dmitry A. Rodionov;Chen Yang;Xiaoqing Li;Andrei L. Osterman;Etienne Dervyn;Oleg V. Geydebrekht;Samantha B. Reed;Margaret F. Romine;Frank R. Collart;James H. Scott;Jim K. Fredrickson;Alexander S. Beliaev
Abstract
The ability to use lactate as a sole source of carbon and energy is one of the key metabolic signatures of Shewanellae, a diverse group of dissimilatory metal-reducing bacteria commonly found in aquatic and sedimentary environments. Nonetheless, homology searches failed to recognize orthologs of previously described bacterial d- or l-lactate oxidizing enzymes (Escherichia coli genes dld and lldD) in any of the 13 analyzed genomes of Shewanella spp. By using comparative genomic techniques, we ide
This paper has been withdrawn.