Common Genetic Variants in the PSCA Gene Influence Gene Expression and Bladder Caancer Risk
Yi-Ping Fu;Indu Kohaar;Nathaniel Rothman;Julie Earl;Jonine D. Figueroa;Yuanqing Ye;Núria Malats;Wei Tang;Luyang Liu;Montserrat Garcia-Closas;Brian Muchmore;Nilanjan Chatterjee;McAnthony Tarway;Manolis Kogevinas;Patricia Porter-Gill;Dalsu Baris;Adam Mumy;Demetrius Albanes;Mark P. Purdue;Amy Hutchinson;Alfredo Carrato;Adonina Tardón;Consol Serra;Reina García-Closas;Josep Lloreta;Alison Johnson;Molly Schwenn;Margaret R. Karagas;Alan Schned;W. Ryan Diver;Susan M. Gapstur;Michael J. Thun;Jarmo Virtamo;Stephen J. Chanock;Joseph F. Fraumeni;Jr.;Debra T. Silverman;Xifeng Wu;Francisco X. Real;Ludmila Prokunina-Olsson
Abstract
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs within 100 Kb of rs2294008 in addition to 33 markers genotyped in one of the reported genome-wide association study in 8,652 subjects. A multivariable logistic regression model adjusted for rs2294008 revealed a unique signal, rs2978974 (r2 = 0.02, D′ = 0.19 with rs2294008). In the combine