Background: Dietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown.
Methods: As part of a population-based case-control study of skin and bladder cancer from the USA, we evaluated relationships between consumption of dietary factors and arsenic concentrations in toenail clippings. Consumption of each dietary factor was determined from a validated food frequency questionnaire. We used general linear models to examine the associations between toenail arsenic and each dietary factor, taking into account potentially confounding effects.
Gruber, Joann F.; Karagas, Margaret R.; Gilbert-Diamond, Diane; Bagley, Pamela J.; Zens, M Scot; Sayarath, Vicki; Punshon, Tracy; Morris, J Steven; and Cottingham, Kathryn L., "Associations between Toenail Arsenic Concentration and Dietary Factors in a New Hampshire Ppopulation" (2012). Open Dartmouth: Faculty Open Access Articles. 1553.