Document Type

Article

Publication Date

12-2012

Publication Title

PLoS Computational Biology

Abstract

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.

DOI

10.1371/journal.pcbi.1002822

Share

COinS