Breast Cancer Research
Geisel School of Medicine
Introduction: Nationally, 25% to 50% of patients undergoing lumpectomy for local management of breast cancer require a secondary excision because of the persistence of residual tumor. Intraoperative assessment of specimen margins by frozen-section analysis is not widely adopted in breast-conserving surgery. Here, a new approach to wide-field optical imaging of breast pathology in situ was tested to determine whether the system could accurately discriminate cancer from benign tissues before routine pathological processing.
Laughney AM, Krishnaswamy V, Rizzo EJ, Schwab MC, Barth RJ Jr, Cuccia DJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA. Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging. Breast Cancer Res. 2013;15(4):R61. doi: 10.1186/bcr3455. PMID: 23915805; PMCID: PMC3979079.
Dartmouth Digital Commons Citation
Laughney, Ashley M.; Krishnaswamy, Venkataramanan; Rizzo, Elizabeth J.; Schwab, Mary C.; Barth, Richard J.; Cuccia, David J.; Tromberg, Bruce J.; Paulsen, Keith D.; Pogue, Brian W.; and Wells, Wendy A., "Spectral Discrimination of Breast Pathologies in Situ Using Spatial Frequency Domain Imaging" (2013). Dartmouth Scholarship. 1611.