Breast Cancer Research
Introduction: Nationally, 25% to 50% of patients undergoing lumpectomy for local management of breast cancer require a secondary excision because of the persistence of residual tumor. Intraoperative assessment of specimen margins by frozen-section analysis is not widely adopted in breast-conserving surgery. Here, a new approach to wide-field optical imaging of breast pathology in situ was tested to determine whether the system could accurately discriminate cancer from benign tissues before routine pathological processing.
Laughney, Ashley M.; Krishnaswamy, Venkataramanan; Rizzo, Elizabeth J.; Schwab, Mary C.; Barth, Richard J.; Cuccia, David J.; Tromberg, Bruce J.; Paulsen, Keith D.; Pogue, Brian W.; and Wells, Wendy A., "Spectral Discrimination of Breast Pathologies in Situ Using Spatial Frequency Domain Imaging" (2013). Open Dartmouth: Faculty Open Access Articles. 1611.