Phosphatidic Acid Phospholipase A1 Mediates ER–Golgi Transit of a Family of G Protein–Coupled Receptors
Govind Kunduri;Changqing Yuan;Velayoudame Parthibane;Katherine M. Nyswaner;Ritu Kanwar;Kunio Nagashima;Steven G. Britt;Nickita Mehta;Varshika Kotu;Mindy Porterfield;Michael Tiemeyer;Patrick J. Dolph;Usha Acharya;Jairaj K. Acharya
Abstract
Cytosolic phosphatidic acid phospholipase A1 interacts with COPII protein family members and is required for the anterograde trafficking of GPCRs.The coat protein II (COPII)–coated vesicular system transports newly synthesized secretory and membrane proteins from the endoplasmic reticulum (ER) to the Golgi complex. Recruitment of cargo into COPII vesicles requires an interaction of COPII proteins either with the cargo molecules directly or with cargo receptors for anterograde trafficking. We s
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