Trans-Ethnic Genome-Wide Association Study of Colorectal Cancer Identifies a New Susceptibility Locus in VTI1A
Hansong Wang;Terrilea Burnett;Suminori Kono;Christopher Haiman;Motoki Iwasaki;Lynne Wilkens;Lenora W.M. Loo;David Van Den Berg;Laurence Kolonel;Brian Henderson;Temitope Keku;Robert Sandler;Lisa Signorello;William Blot;Polly Newcomb;Mala Pande;Christopher Amos;Dee West;Stéphane Bézieau;Sonja Berndt;Brent Zanke;Li Hsu;Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO);Noralane Lindor;Robert Haile;John Hopper;Mark Jenkins;Steven Gallinger;Graham Casey;Colon Cancer Family Registry (CCFR);Stephanie Stenzel;Fredrick Schumacher;Ulrike Peters;Stephen Gruber;Colorectal Transdisciplinary Study (CORECT);Shoichiro Tsugane;Daniel Stram;Loïc Le Marchand
Abstract
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P < 5×10−8) in 16,823 cases and 18,211 controls of European ancestry. This st