Journal of Neuroinflammation
Background: The immunological response during the first 24 hours after traumatic brain injury (TBI) may be a critical therapeutic interval for limiting the secondary neuronal damage that is influenced by enhanced inflammatory mediator expression.
Methods: To gain further insight of the early injury response, we examined the expression of several inflammatory genes by real-time qPCR as a function of time or distance from injury in two distinct mammalian models: an ex vivo mouse cortical slice injury system and an in vivo piglet model of brain injury.
Graber, David J.; Costine, Beth A.; and Hickey, William F., "Early Inflammatory Mediator Gene Expression in Two Models of Traumatic Brain Injury: Ex Vivo Cortical Slice in Mice and In Vivo Cortical Impact in Piglets" (2015). Open Dartmouth: Faculty Open Access Articles. 1647.