Journal of Oral Microbiology
Geisel School of Medicine
Actinomyces oris is a Gram-positive bacterium that has been associated with healthy and diseased sites in the human oral cavity. Most pathogenic bacteria require iron to survive, and in order to acquire iron in the relatively iron-scarce oral cavity A. oris has been shown to produce iron-binding molecules known as siderophores. The genes encoding these siderophores and transporters are thought to be regulated by the amount of iron in the growth medium and by the metal-dependent repressor, AmdR, which we showed previously binds to the promoter of proposed iron-regulated genes.
Dartmouth Digital Commons Citation
Mulé, Matthew P.; Giacalone, David; Lawlor, Kayla; Golden, Alexa; Cook, Caroline; Lott, Thomas; Aksten, Elizabeth; O'Toole, George A.; and Bergeron, Lori J., "Iron-Dependent Gene Expression in Actinomyces Oris" (2015). Dartmouth Scholarship. 1665.