Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics

Serena Brundu
Linda Palma
Giusi Giada Picceri
Daniela Ligi

Serena Brundu;Linda Palma;Giusi Giada Picceri;Daniela Ligi;Chiara Orlandi;Luca Galluzzi;Laura Chiarantini;Anna Casabianca;Giuditta Fiorella Schiavano;Martina Santi;Ferdinando Mannello;Kathy Green;Michaël Smietana;Mauro Magnani;Alessandra Fraternale


Injection of the LP-BM5 murine leukemia virus into mice causes murine AIDS, a disease characterized by many dysfunctions of immunocompetent cells. To establish whether the disease is characterized by glutathione imbalance, reduced glutathione (GSH) and cysteine were quantified in different organs. A marked redox imbalance, consisting of GSH and/or cysteine depletion, was found in the lymphoid organs, such as the spleen and lymph nodes. Moreover, a significant decrease in cysteine and GSH levels