Overexpression of Core-Binding Factor Alpha (CBF Alpha) Reverses Cellular Transformation by the CBF Beta-Smooth Muscle Myosin Heavy Chain Chimeric Oncoprotein.

A Hajra
P Liu
N Speck
F. Collins

A Hajra;P Liu;N Speck;F Collins


A fusion between the transcription factor core-binding factor beta (CBF beta; also known as PEBP2 beta) and the tail region of smooth muscle myosin heavy chain (SMMHC) is generated by an inversion of chromosome 16 [inv(16) (p13q22)] associated with the M4Eo subtype of acute myeloid leukemia. We have previously shown that this CBF beta-SMMHC chimeric protein can transform NIH 3T3 cells and that this process requires regions of the chimeric protein necessary for association with the CBF alpha subu