Title
A New VISTA on combination therapy for negative checkpoint regulator blockade
Document Type
Article
Publication Date
12-20-2016
Publication Title
Journal for ImmunoTherapy of Cancer
Department
Geisel School of Medicine
Abstract
Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, clinical trials demonstrating the efficacy of blocking antibodies against these molecules have invigorated the field of immunotherapy. In this review, we discuss the current understanding on established NCR blockade and how strategic combination therapy with anti-VISTA antibody can be used to target multiple non-redundant NCR pathways.
DOI
10.1186/s40425-016-0190-5
Dartmouth Digital Commons Citation
Deng, Jie; Le Mercier, Isabelle; Kuta, Anna; and Noelle, Randolph J., "A New VISTA on combination therapy for negative checkpoint regulator blockade" (2016). Dartmouth Scholarship. 193.
https://digitalcommons.dartmouth.edu/facoa/193