BioMed Central Structural Biology
Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process are still structurally uncharacterized, and remain outstanding questions in the field. Perturbing the motor by introducing point mutations could stabilize transitional or unstable states, providing critical information about these rarer states.
Heuston, Elisabeth; Bronner, C. Eric; Kull, F Jon; and Endow, Sharyn A., "A Kinesin Motor in a Force-Producing Conformation" (2010). Open Dartmouth: Peer-reviewed articles by Dartmouth faculty. 2410.