Document Type

Article

Publication Date

7-5-2010

Publication Title

BioMed Central Structural Biology

Abstract

Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process are still structurally uncharacterized, and remain outstanding questions in the field. Perturbing the motor by introducing point mutations could stabilize transitional or unstable states, providing critical information about these rarer states.

DOI

10.1186/1472-6807-10-19

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