Antimicrobial Agents and Chemotherapy
Thayer School of Engineering
More than 2 decades of study support the hypothesis that alginate lyases are promising therapeutic candidates for treating mucoid Pseudomonas aeruginosa infections. In particular, the enzymes' ability to degrade alginate, a key component of mucoid biofilm matrix, has been the presumed mechanism by which they disrupt biofilms and enhance antibiotic efficacy. The systematic studies reported here show that, in an in vitro model, alginate lyase dispersion of P. aeruginosa biofilms and enzyme synergy
Lamppa JW, Griswold KE. Alginate lyase exhibits catalysis-independent biofilm dispersion and antibiotic synergy. Antimicrob Agents Chemother. 2013 Jan;57(1):137-45. doi: 10.1128/AAC.01789-12. Epub 2012 Oct 15. PMID: 23070175; PMCID: PMC3535929.
Dartmouth Digital Commons Citation
Lamppa, John W. and Griswold, Karl E., "Alginate Lyase Exhibits Catalysis-Independent Biofilm Dispersion and Antibiotic Synergy" (2013). Dartmouth Scholarship. 2527.