Document Type

Article

Publication Date

1-1-2000

Publication Title

The Journal of Experimental Medicine

Department

Geisel School of Medicine

Abstract

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.

DOI

10.1084/jem.191.2.381

Original Citation

Garceau N, Kosaka Y, Masters S, Hambor J, Shinkura R, Honjo T, Noelle RJ. Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. J Exp Med. 2000 Jan 17;191(2):381-6. doi: 10.1084/jem.191.2.381. PMID: 10637282; PMCID: PMC2195761.

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