The Journal of Experimental Medicine
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.
Garceau, Norman; Kosaka, Yoko; Masters, Sally; Hambor, John; Shinkura, Reiko; Honjo, Tasuko; and Noelle, Randolph J., "Lineage-Restricted Function of Nuclear Factor KappaB-Inducing Kinase (NIK) in Transducing Signals Via CD40." (2000). Open Dartmouth: Faculty Open Access Articles. 2890.