Title
Multichannel Diffuse Optical Raman Tomography for Bone Characterization In Vivo: a Phantom Study
Document Type
Article
Publication Date
8-30-2012
Publication Title
Biomedical Optics Express
Department
Thayer School of Engineering
Abstract
Raman spectroscopy is used to gather information on the mineral and organic components of bone tissue to analyze their composition. By measuring the Raman signal of bone through spatially offset Raman spectroscopy the health of the bone can be determined. We’ve customized a system with 8 collection channels that consist of individual fibers, which are coupled to separate spectrometers and cooled CCDs. This parallel detection system was used to scan gelatin phantoms with Teflon inclusions of two sizes. Raman signals were decoupled from the autofluorescence background using channel specific polynomial fitting. Images with high contrast to background ratios of Raman yield and accurate spatial resolution were recovered using a model-based diffuse tomography approach.
DOI
10.1364/BOE.3.002299
Dartmouth Digital Commons Citation
Demers, Jennifer-Lynn H.; Davis, Scott C.; Pogue, Brian W.; and Morris, Michael D., "Multichannel Diffuse Optical Raman Tomography for Bone Characterization In Vivo: a Phantom Study" (2012). Dartmouth Scholarship. 2967.
https://digitalcommons.dartmouth.edu/facoa/2967