Department of Biological Sciences
A role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory. Using two independent dSK alleles, a null mutation and a dominant negative subunit, we show that while dSK negatively regulates the acquisition of short-term memory 30 min after a short training session, it is required for normal long-term memory 24 h after extended training. These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity.
Abou Tayoun AN, Pikielny C, Dolph PJ. Roles of the Drosophila SK channel (dSK) in courtship memory. PLoS One. 2012;7(4):e34665. doi: 10.1371/journal.pone.0034665. Epub 2012 Apr 11. PMID: 22509342; PMCID: PMC3324495.
Dartmouth Digital Commons Citation
Abou Tayoun, Ahmad N.; Pikielny, Claudio; and Dolph, Patrick J., "Roles of the Drosophila SK Channel (dSK) in Courtship Memory" (2012). Dartmouth Scholarship. 3177.