Document Type
Article
Publication Date
2005
Publication Title
Synlett
Abstract
An account is given of the author’s several approaches to the synthesis of the parent chromophore of phytochrome (1), a protein-bound linear tetrapyrrole derivative that controls photomorphogenesis in higher plants. These studies culminated in enantioselective syntheses of both (2R)- and (2S)-phytochromobilin (4), as well as several 13C-labeled derivatives designed to probe the site of Z,E-isomerization during photoexcitation. When reacted in vitro, synthetic 2R-4 and recombinant-derived phytochrome apoprotein N-C produced a protein-bound chromophore with identical difference spectra to naturally occurring 1.
DOI
10.1055/s-2005-918956
Dartmouth Digital Commons Citation
Jacobi, Peter A.; Odeh, Imad; Buddhu, Subhas; Cai, Guolin; Rajeswari, Sundaramoorthi; Fry, Douglas; Zheng, Wanjun; DeSimone, Robert W.; Guo, Jiasheng; Coutts, Lisa D.; Hauck, Sheila I.; Leung, Sam H.; Ghosh, Indranath; and Pippin, Douglas, "Synthetic Studies in Phytochrome Chemistry" (2005). Open Dartmouth: Peer-reviewed articles by Dartmouth faculty. 3630.
https://digitalcommons.dartmouth.edu/facoa/3630