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Nucleic Acids Research


Geisel School of Medicine


The two predominant types of nicotinic acetylcholine receptors expressed in mammalian muscle differ with respect to a variety of electrophysiological and biochemical properties. A developmental, innervation-dependent switch in the subunit structure of the receptor, in which a y subunit is replaced by an E subunit, is thought to account, in large part, for these differences(1). Because of the interest in the regulatory mechanisms underlying this switch, much attention has focused on these two subunits. Here I report the nucleotide and deduced amino acid sequences of a clone coding for the mouse muscle E subunit isolated from a cDNA library constructed using poly(A)+ RNA isolated from innervated mouse diaphragm. Assignment of an initiator methionine is based on sequence comparison with the mouse genomic E subunit clone(2).



Original Citation

Gardner PD. Nucleotide sequence of the epsilon-subunit of the mouse muscle nicotinic acetylcholine receptor. Nucleic Acids Res. 1990;18(22):6714. doi:10.1093/nar/18.22.6714

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