Nucleic Acids Research
The two predominant types of nicotinic acetylcholine receptors expressed in mammalian muscle differ with respect to a variety of electrophysiological and biochemical properties. A developmental, innervation-dependent switch in the subunit structure of the receptor, in which a y subunit is replaced by an E subunit, is thought to account, in large part, for these differences(1). Because of the interest in the regulatory mechanisms underlying this switch, much attention has focused on these two subunits. Here I report the nucleotide and deduced amino acid sequences of a clone coding for the mouse muscle E subunit isolated from a cDNA library constructed using poly(A)+ RNA isolated from innervated mouse diaphragm. Assignment of an initiator methionine is based on sequence comparison with the mouse genomic E subunit clone(2).
Dartmouth Digital Commons Citation
Gardner, P D., "Nucleotide Sequence of the Epsilon-Subunit of the Mouse Muscle Nicotinic Acetylcholine Receptor" (1990). Open Dartmouth: Peer-reviewed articles by Dartmouth faculty. 3791.