Molecular Biology of the Cell
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
Wickner, William and Rizo, Josep, "A Cascade of Multiple Proteins and Lipids Catalyzes Membrane Fusion" (2017). Open Dartmouth: Peer-reviewed articles by Dartmouth faculty. 3840.