Molecular Biology of the Cell
Geisel School of Medicine
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
Wickner W, Rizo J. A cascade of multiple proteins and lipids catalyzes membrane fusion. Mol Biol Cell. 2017;28(6):707-711. doi:10.1091/mbc.E16-07-0517
Dartmouth Digital Commons Citation
Wickner, William and Rizo, Josep, "A Cascade of Multiple Proteins and Lipids Catalyzes Membrane Fusion" (2017). Dartmouth Scholarship. 3840.