Document Type


Publication Date


Publication Title

Biomedical Optics Express


Thayer School of Engineering


Integration of magnetic resonance imaging (MRI) and near-infrared spectral tomography (NIRST) has yielded promising diagnostic performance for breast imaging in the past. This study focused on whether MRI-guided NIRST can quantify hemoglobin concentration using only continuous wave (CW) measurements. Patients were classified into four breast density groups based on their MRIs. Optical scattering properties were assigned based on average values obtained from these density groups, and MRI-guided NIRST images were reconstructed from calibrated CW data. Total hemoglobin (HbT) contrast between suspected lesions and surrounding normal tissue was used as an indicator of the malignancy. Results obtained from simulations and twenty-four patient cases indicate that the diagnostic power when using only CW data to differentiate malignant from benign abnormalities is similar to that obtained from combined frequency domain (FD) and CW data. These findings suggest that eliminating FD detection to reduce the cost and complexity of MRI-guided NIRST is possible.



Original Citation

Jinchao Feng, Shudong Jiang, Brian W. Pogue, and Keith D. Paulsen, "Performance assessment of MRI guided continuous wave near-infrared spectral tomography for breast imaging," Biomed. Opt. Express 12, 7657-7672 (2021)