Title

Crystallization of the Staphylococcus Aureus MazF mRNA Interferase

Document Type

Article

Publication Date

3-2011

Publication Title

Acta Crystallographica. Section F - Structural Biology and Crystallization Communications

Abstract

mazEF modules encode toxin–antitoxin pairs that are involved in the bacterial stress response through controlled and specific degradation of mRNA. Staphylococcus aureus MazF and MazE constitute a unique toxin–antitoxin module under regulation of the sigB operon. A MazF-type mRNA interferase is combined with an antitoxin of unknown fold. Crystals of S. aureus MazF (SaMazF) were grown in space group P212121. The crystals diffracted to 2.1 Å resolution and are likely to contain two SaMazF dimers in the asymmetric unit.

DOI

10.1107/S1744309111000571

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