Antimicrobial Agents and Chemotherapy
The spread of drug-resistant bacterial pathogens is a growing global concern and has prompted an effort to explore potential adjuvant and alternative therapies derived from nature's repertoire of bactericidal proteins and peptides. In humans, the airway surface liquid layer is a rich source of antibiotics, and lysozyme represents one of the most abundant and effective antimicrobial components of airway secretions. Human lysozyme is active against both Gram-positive and Gram-negative bacteria, ac
Teneback, Charlotte C.; Scanlon, Thomas C.; Wargo, Matthew J.; Bement, Jenna L.; Griswold, Karl E.; and Leclair, Laurie W., "Bioengineered Lysozyme Reduces Bacterial Burden and Inflammation in a Murine Model of Mucoid Pseudomonas aeruginosa Lung Infection" (2013). Open Dartmouth: Faculty Open Access Articles. 468.