Antimicrobial Agents and Chemotherapy
Geisel School of Medicine
Surface-associated bacterial communities known as biofilms are an important source of nosocomial infections. Microorganisms such as Pseudomonas aeruginosa can colonize the abiotic surfaces of medical implants, leading to chronic infections that are difficult to eradicate. Our study demonstrates that polysorbate 80 (PS80), a surfactant commonly added to food and medicines, is able to inhibit biofilm formation by P. aeruginosa on a variety of surfaces, including contact lenses.
Toutain-Kidd CM, Kadivar SC, Bramante CT, Bobin SA, Zegans ME. Polysorbate 80 inhibition of Pseudomonas aeruginosa biofilm formation and its cleavage by the secreted lipase LipA. Antimicrob Agents Chemother. 2009 Jan;53(1):136-45. doi: 10.1128/AAC.00500-08. Epub 2008 Oct 27. PMID: 18955535; PMCID: PMC2612155.
Dartmouth Digital Commons Citation
Toutain-Kidd, C M.; Kadivar, S C.; Bramante, C T.; Bobin, S A.; and Zegans, Michael E., "Polysorbate 80 Inhibition of Pseudomonas aeruginosa Biofilm Formation and Its Cleavage by the Secreted Lipase LipA" (2009). Dartmouth Scholarship. 471.