ARKIVOC - Online Journal of Organic Chemistry
Alkyne acid 10 was prepared in enantioselective fashion from allylic ester derivative (R)-18 via an E-selective Ireland-Claisen rearrangement followed by Si-assisted elimination of HBr. The present route offers significant advantages in terms of both scalability and overall yield compared to that previously described. Alkyne acid 10 is an attractive ring-C precursor for an ongoing synthesis of cobyric acid.
Wang, Hui and Jacobi, Peter A., "An Improved Synthesis of a Ring-C Precursor to Cobyric Acid" (2010). Open Dartmouth: Faculty Open Access Scholarship. 505.